Human subjects involved had legal capacity to give voluntary consent. The protocol was approved by the Institutional Review Board of National Cheng Kung University Hospital (IRB Approval No. The clinical investigations were conducted according to the principles expressed in the Nuremberg Code and Declaration of Helsinki. The cellular function of primary cells derived from the patients was compared with that of normal subjects. This mutation site is first reported as a pathogenic mutation. Schwartz–Jampel syndrome is a rare autosomal recessive disease with a prevalence of G on HSPG2 causing a p.Cys375Trp change in domain II of the perlecan core protein from two familial cases. Patients with this mutation showed more neuromuscular instability and relatively mild skeletal abnormality comparing with previously reported cases. At cellular levels, mutant primary fibroblasts had reduced levels of secreted perlecan and impaired migration ability but normal capability of proliferation. Short exercise test for myotonia showed Fournier pattern I. Needle electromyography revealed extensive complex repetitive discharges and multiple polyphasic motor unit action potentials in axial and limb muscles at rest. Various in silico software applications predicted the mutation to be pathogenic. The pathogenic nature of this missense mutation was demonstrated by in silico pathogenicity assessment, clinical presentations, and cellular function of primary fibroblast derived from patients. This mutation carried by the asymptomatic parents was previously registered in a single-nucleotide polymorphism database of the National Institutes of Health as a coding sequence variant rs543805444. Herein, we identified a new pathogenic mutation site (NM_005529.6:c.1125C>G p.Cys375Trp) of HSPG2 leading to Schwartz–Jampel syndrome by whole-exome sequencing. Its cardinal symptoms are skeletal dysplasia and neuromuscular hyperactivity. Schwartz–Jampel syndrome is a rare autosomal recessive disease caused by mutation in the heparan sulfate proteoglycan 2 ( HSPG2) gene. 6Institute of Basic Medical Sciences and Department of Biochemistry and Molecular Biology, National Cheng Kung University College of Medicine, Tainan, Taiwan.5Department of Genomic Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.4Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.3Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.2Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.1Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Po-Yu Lin 1, Jia-Horung Hung 2,3, Chao-Kai Hsu 4,5, Yao-Tsung Chang 6 and Yuan-Ting Sun 1,5 *
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However, the update left some users unhappy, which made Apple revert Safari back to its old design and make the new interface optional for users. Last year, Apple introduced a completely redesigned version of Safari that unified the address bar with the tab bar. Safari is the default web browser for Apple devices such as the iPhone and the Mac, which certainly contributes to it being the second most used web browser worldwide. While StatCounter or even Apple doesn’t provide details on the reason why Safari is losing users, we can easily make a few assumptions about it. It’s worth noting that Safari is only available on macOS (when it comes to desktop), while other web browsers can be installed on Macs and Windows PCs. However, Safari has already lost its second place as the most used desktop web browser in Europe. When considering the US market, Safari still has an advantage against Microsoft Edge with 18.12% versus 12.09%, respectively. If Safari continues to lose users, it will probably slip to the third or fourth place in the ranking over the next few months. Unsurprisingly, Google Chrome is still in first place with 65.38% of the share.īy comparison, 10.38% of desktop users were surfing the web with Safari in January 2021, which suggests that Apple’s web browser has been losing ground to other alternatives. Firefox, which had only 8.1% share in January 2021, has gained new users during the past few months and now has 9.18% of the desktop market share. While Safari is used by 9.84% of desktop users, Microsoft Edge is right behind with 9.54% market share. However, new data suggests that Safari is about to lose its second place in the ranking to its competitors.Īs shown by StatCounter (via TechRadar), Safari remains the second most-used desktop web browser in the world as of January 2022, but two of its competitors are close to taking over second place this time around. Apple’s Safari web browser has never been as popular as Google Chrome, which dominates the worldwide market share, but it has been consolidated as the second most-used browser for a long time. Migrants are often forced to find alternative means of crossing a border, and the new routes are often more dangerous, even deadly, Jones said.įor example, in the 2000s, more than 2,000 migrants a year died trying to cross into the U.S. “What scholars have found is that walls and barriers seem to have very little impact,” Jones said.Ĭountries are “investing a lot of money on something you can go over, under or around,” Vallet said. “The other being somebody you don’t know, somebody you fear … the fence being the solution.” “It’s the fear of the other,” Vallet said. Vallet said Trump was using the theory of the “clash of civilizations” - that in the post-Cold War world, the main course of conflict will be over cultural and religious identity. It’s a powerful symbol of action to counter the things that people are afraid of.” Jones, the academic from Hawaii, noted that “a wall symbolizes action. “It’s not about stopping people it’s about communicating.” “What politicians want is to communicate to the electorate that something is being done,” Madsen said. “Today, the walls are really between countries that have economic discrepancies.”īarriers also are being used to send a message, not only to outsiders but to a national audience, border experts said.ĭuring his election campaign, Trump said the U.S.-Mexico wall would be built to keep out Mexicans he described as “criminals, drug dealers, rapists.” Madsen, associate professor in geography at Ohio State University at Newark. “What would be unusual would be to have a wall between countries that are equivalent economically,” said Kenneth D. Typically, the goal is to prevent people from poorer nations of the global South from entering the more wealthy and industrialized nations of the North, experts said. “Democracies are picking up on the idea of keeping people out.” “It’s more of an effort to control migration than for peacekeeping,” Vallet said. Though most barriers - concrete walls, barbed-wire fences and sand berms - were constructed to deter trafficking and terrorists, newer barriers aim to stop migrants. ⦿ Twin 3: The Arpeggiator Lock option is now always disabled for new plugin instances. ⦿ Volcano 3: Fixed an issue in the mono version of the plugin where filters removed from the interface could still be in effect. ⦿ Volcano 3: Fixed an issue where entering text for the peak value in the parameter value display changed the frequency when the piano display was on. ⦿ Volcano 3: Fixed a bug that could cause possible clicks or noise when modulating filter peaks around zero. ⦿ Twin 3: Changed the design of the options icon in the preset browser to make it easier to find. FabFilter Timeless 2 is not only a flexible, perfectly modeled tape delay plugin with unique filters - it also offers chorus, flanger, phaser and scratch. ⦿ Twin 3: Fixed a bug where the main parameter Frequency Offset was ignored for filters with panning and unmodulated filter frequency. ⦿ Pro-L 2: Added Auto-Reset option for volume metering, available as a toggle in the Loudness Time Scale menu. If this option is enabled, volume measurement and clipping will be reset each time playback is started in the DAW. These are the results of various tweaking over the years. Thus it has become my go-to delay once again. ⦿ Pro-G: Added visualization of the density spectrum in the sidechain filter controller, similar to how it is displayed in Pro-DS. In the past few years Ive learned how to tweak Timeless 2 so that its actually useful in a musical context instead of just a sound design tool with crazy noises. ⦿ Pro-DS and Pro-G: Added support for various interface sizes and full screen mode. Volcano is one of the coolest filtering plugins I've had the joy of playing with. Pro-R has very in-depth controls and filters that allow you to create basically any reverb sound you can imagine. ⦿ Timeless 3, Volcano 3, Twin 3 and Saturn 2: Added Auto-Collapse Sources option, accessible via the Add Source ‘+’ button menu. If this option is enabled, when one source interface is expanded, the others are automatically collapsed (default behavior). If the option is disabled, multiple source interfaces can be deployed at the same time. Timeless is a super powerful delay plugin, way better than any stock one in a DAW. ⦿ Timeless 3, Volcano 3, Twin 3 and Saturn 2: Added Show Source Flow option available via Add Source ‘+’ button menu. ⦿ Added support for programmatic MIDI changes in VST3 plugins. FabFilter Timeless 3 is a versatile, vintage-sounding tape delay, which will fully satisfy your everyday delay needs. ⦿ Added right-click context menu for preset button with Save and Save As options. In Twin 3, this also allows you to mark a preset as a favorite. ⦿ Reduced CPU spikes when changing oversampling or high quality mode in Pro and Creative plugins. ⦿ All Pro and Creative plugins now support interface scaling. The resize button at the bottom right of the UI now offers a Scaling sub-menu where you can zoom in or out on the entire UI, such as 125%, 150%, etc. ⦿ Added Apple Silicon support for all AAX plugins. We’ve just released an update to all FabFilter plugins that brings support for AAX Apple Silicon as well as bug fixes, improvements and some small new features. All plugins have been updated with UI scaling and more ! Pidgey 100% perfect IV stats in Pokémon Go This could be anything from a warning, to a lifetime ban.Watch on YouTube Battling and catching the latest Ultra Beast, Guzzlord, in Pokémon Go. If you are using a bot to alter the Pokemon Go game, as well as using unlicensed third-party apps, you may suffer the consequences. Will Pokemon Go Ban Me If I Use These Tools in Finding Pokemons? However, some may have in-app purchasing. However, after a few tweaks to get rid of features that were considered cheating, Pokemon Go developers are rumored to be working WITH the app. The app was initially banned by many servers. It is also always updating new safety measures. It also tells you how long the Pokemon will last. □ FAQ What Is FastPokeMap?įastPokeMap is an app that allows you to find Pokemon that have already been discovered by other players. If you have any queries related to the FastPokeMap alternatives for Pokémon Go? Please feel free to leave a comment below and stay tuned for many more articles. Go and catch your favorite Pokemon and be a winner! It lets you with the free scanning service for popular areas. All the Pokemon spawn data shown on the map are outsourced from other third-party reputable scanner and tracker channels. PokeFetch is the best alternative that lets you track Pokemon using a real-time Pokemon GO map. There are a number of FastPokeMap alternatives, but here we have listed the best alternative for your Poke Map. But chill guys, there are best alternatives out there. Gamers are stuck trying to find and catch Pokémon the old fashioned way: actually walking around. It helps you save your precious time, efforts, and energy that you might have wasted roaming here and there. FastPokeMap will tell exactly where you will find a Pokémon, the Pokémon you are going to catch, and for how long it will be going to stay there. The best interesting part about the FastPokeMap tracker is that it will not only show you the Pokémon position, along with information about Pokémon’s name, looks, and the estimated expiration time. The best part is that with just a simple click on the map, the FPM trackers will start a scan around the selected area and then reveal the exact position of all the Pokémon found within the highlighted radius. As a result, you can easily find all the Pokémon hiding nearby, without roaming here and there. What Is FastPokeMap?įastPokeMap is a third party Pokémon Tracker service created by the Pokémon Go enthusiasts to help the Pokémon Go users. All of them works awesome and will help you find and track Pokemon around your area. They have found some of the best FastPokeMap alternatives for Pokemon GO. Now, to help you guys Pokemon trainers have found rare and legendary Pokemon. The best feature is that it shows the duration after which the Pokemon will disappear from that location. Pokemon GO is a Pokemon tracker game for Pokemon lovers which allows users to trace the exact location of the Pokemon that you need to catch. It hardly matters if you experience with Pokémon Go in catching a Pidgey or if you don’t have any actual track record of making this work. To let you experience the real treasure we have the Best FastPokeMap alternatives. Are you found of searching things like a treasure hunt? Surely that’s one of the amazing things. Many people have MRI evidence of herniated disks and have no back pain at all. Herniated lumbar disc is a displacement of disc material (nucleus pulposus or annulus fibrosis) beyond the intervertebral disc space. This bulging material may contact or pinch the thecal sac or. If an imaging test indicates that you have a herniated disk, that disk might not be the cause of your back pain. This term means a generalized disc bulge of one of spinal discs of the neck (cervical spine). The irritation can be from compression of the nerve or, much more commonly, the herniation causes a painful inflammation of the nerve root. Only the small area of the crack is affected.Ĭompared with a bulging disk, a herniated disk is more likely to cause pain because it generally protrudes farther and is more likely to irritate nerve roots. Herniated disks are also called ruptured disks or slipped disks, although the whole disk does not rupture or slip. This is called a herniated or bulging disc. Only the outer layer of tough cartilage is involved.Ī herniated disk, on the other hand, results when a crack in the tough outer layer of cartilage allows some of the softer inner cartilage to protrude out of the disk. When this happens, the soft, inner part of the disc bulges out. These changes can cause the outer layer of the disk to bulge out fairly evenly all the way around its circumference - so it looks a little like a hamburger that's too big for its bun.Ī bulging disk doesn't always affect the entire perimeter of a disk, but at least a quarter if not half of the disk's circumference is usually affected. You can find detailed information concerning endoscopic surgery in. Over time, disks dehydrate and their cartilage stiffens. Through this small opening, we work with small instruments to remove the disc herniation. Disc protrusions (often called herniated, bulging or prolapsed discs) are often found in people without back pain. Here, doctors and physical therapists share exercises for a herniated disc to ease pain while also addressing the root problem. cushioning the thousands of little impacts your body undergoes every day. Disks show signs of wear and tear with age. Its quite possible youve experienced a herniated disc but never knew about. Physical gift card codes can only be applied once and are only valid on for orders shipping with the United States and Canada. Please note that all physical gift card codes must be added to your shopping cart prior to completing the checkout. After you enter the gift card code into the field, click “APPLY”. On the righthand side of the page, you will see a box where a “Gift card or discount” code can be applied. Click the bag icon in the top right corner and click on “CHECKOUT”. Select and add all your Copper Fit products to your shopping cart. Only one discount code per order is permitted.Īpplying a Discount Code from a Physical Gift Card does not allow you to combine more than one discount code. Digital gift cards and discount codes can only be applied once and are only valid on for orders shipping with the United States and Canada. Please note that gift card and discount codes must be added to your shopping cart prior to the completing checkout. Enter your gift card or code into the field and click “APPLY”. Promotional discounts are not eligible on gift card purchases.Īpplying a Digital Gift Card or Promotional Discount The email will be sent to the purchaser's email inbox (which is the email entered at checkout), but you can forward the gift card email if you are gifting to others. Upon purchase, you will receive an email with a unique code that is redeemable at check out. Our gift cards can be used online on and never expire. You can shop Copper Fit Digital Gift Cards HERE. For more information on where to purchase Copper Fit products internationally, please email us at Gift Cards We currently do not ship internationally. Thank you for your patience.ĭoes Copper Fit ship their product internationally? Please allow 10 – 15 business days for delivery. You can check the status of your shipment by clicking on the tracking link. Tracking will be automatically sent to you via email once your order has been shipped. We use various delivery carriers utilizing standard shipping (DHL, FedEx SmartPost and U.S. If you ordered multiple items, they may to arrive separately from either of our warehouses in CT and NV. It typically takes our fulfillment center 24 – 48 hours to pick, pack and ship your order. How long does it take for my item(s) to be shipped? If you have any questions, feel free to email us at or call 1-85 Monday – Friday 8:00 a.m. If an item has gone out of stock after you’ve ordered it, we will reach out to you and let you know. If you’ve ordered multiple items, they may arrive separately from either our CT or NV warehouse. I ordered two (or more) different items, but I have only received one of them. You can also download Shop, where you can see your order status. Click your tracking number and you will be able to see your order status. Once your order ships, you will receive an email with tracking information. Please set your mailing address to be a physical address for delivery. Order and Delivery StatusĬan I have my order delivered to a PO Box?įedEx does not deliver to PO Boxes. *Please allow 10 days from receipt of your return for credit to be processed. Please include your Order #, complete name, address, daytime telephone number and email address inside the return package when returning your item. If you still have questions about your return, please email send all returns to: If you paid with a Gift Card, we will refund your purchase amount to a new electronic gift card for that amount. Once the return is processed, you’ll get an email that your refund is being processed back to the original form of payment. Please allow 10 days for us to receive and process your return. In order to receive a refund to your original method of payment, please include your order number, complete name, address, a daytime telephone number, and email address inside the return package when returning your item. We encourage you to return your package using a traceable means and whenever possible include the original packaging with shipping label. Return Policy for orders placed online or by phone only:ģ0-Day Money Back Guarantee (Less S&H). For All General Customer Service Inquiries Contact:įor customer service, please call 1-85 or email Monday through Friday, 8:00am to 8:00pm Eastern Time. If you should have any questions about ordering or a question about any of our great products, please feel free to contact us with the information provided below. We apply refunds to the tender with which returned items were purchased. We will always do our best to take care of customers. We stand behind our goods and services and want customers to be satisfied with them. We are committed to providing the best products with the ultimate goal of making our customers happy. You can also navigate to put yourself to risky access if you can’t verify your domain.Īnd enable the drive API for your project. You’ll also require to verify your domain. Provide these ID’s in keeWeb in gdriveClientId & secret option. Navigate to Credentials>Create Credentials>OAuth Client ID.Īnd select the application type as web application.Īnd finally provide your domain & site urls as below & hit create. Select your new keypass & then save it to google drive. Navigate to Plugins>Load Plugin Gallery to install new plugins. Step 5: Install KeeWeb Password Manager Plugins You can select hotkeys, plugins and interaction with usb. Keeweb provides the facility of customization as you want. Step 4: Customize KeeWeb Password Manager On Ubuntu 20.04 You can also add entries,group or template. Once file added, you can see it in the left side of keeweb. In order to sync with online storage select the tools listed & follow the procedure. You can also save your passwords offline and online. Provide the master password, name & do backup of key if you needed.Īnd finally click on “Save to” button to finish setting up. You’ll see the similar page.Ĭlick on the “+” sign to add the new password file.Ĭlick on “new” at the bottom left side & you’ll get the page like below: Now, visit the web browser and type your IP. Run the keeweb image on port 80 by given command. We’ll install Keeweb on Ubuntu 20.04 from the source code. sudo usermod -aG docker $ Step 3: Install KeeWeb On Ubuntu 20.04 نومبر 29 10:21:29 Ubuntu20 systemd: Started Docker Application Container En>Īdd the user to the docker group in order to avoid typing sudo everytime. └─5014 /usr/bin/dockerd -H fd:// -containerd=/run/containerd/con> Loaded: loaded (/lib/systemd/system/rvice enabled vendor prese>Īctive: active (running) since Sun 10:21:29 PKT 3min 8s ago
Want to stay in touch with your customers and audience? Get notified whenever new reviews are posted about your business or service online.Keep track and watch out for sneaky price changes or discounts on a product you’re interested in buying.Monitor your University or school website to get notified about exam results.Track job portals and get notified when a new position is listed.And in this section, you will learn about the most useful ways to leverage website monitoring tools to your advantage. You know how to set up a trigger for when a website changes, connect it to an action, and everything in between.īut how can you leverage this new know-how to save you time and gain a competitive edge? OK, now you’ve got the hang of these web monitoring tools. Popular use cases for website monitoring But then, if you want to go into the deep end and mess around with code, you can go for it! It’s designed in such a way that even if you only want to use the basic features, you can do that easily. Overall, Hexowatch is a great option to look into. If you’re curious, above are all the paid plans they offer. Scrapers are the software tools that extract data from almost any website in a structured format (like a table). If APIs seem way out of your ballpark, web scrapers are your best option. In theory, you can set up a workflow where the APIs of a website that you want to monitor ping your server and get nicely formatted data sent to you instantly.įirst, not all websites have a public API that you can use.Īnd second, monitoring websites using APIs is time-consuming to set up, and you need to know how to code. What if you could ask Google to tell you when these results changed automatically? In the background, Google searched its database and returned the results. After entering search criteria like the destination and date, you press Enter, and voilà, you have a list of flights right in front of you. You may go to a site like Google Flights. Let’s talk about both options briefly.ĪPI stands for “Application Programming Interface,” and it acts as a middleman between two apps that want to communicate with each other and exchange data. If you want to monitor a website, there are two ways to go about it: APIs and data scrapers. Website monitoring: what you need to knowīefore we get to setting up an automation for monitoring website changes, let’s talk about the magic that happens behind the scenes. We are going to use no-code website scraper tools to track a specific field on a website and will notify you when a change is made. In this article, you will learn how to monitor website changes. Fortunately, there is a solution to this - having your computer do this automatically. Of course, you probably know that this is the least productive way you can spend your time. The website is open in front of us, and we keep staring at it, our eyes peeled for a change. It could be for a multitude of things, like checking if a gaming console is back in stock or if the price of a flight ticket has been lowered. Let’s admit it, we’ve all been in a situation like this before. Overall, the Ryzen 7 5800X3D is about 1.7% faster than the Core i9-12900K. The extra 元 cache on Ryzen 7 5800X3D makes a big difference, however. Keep in mind that the Core i9-12900K supports DDR5, though it doesn’t make a huge difference in games. Our tests were run at 1080p with an RTX 3090 and 32GB of DDR4-3200 memory. You can see how the two chips stack up on average in the chart below. The Ryzen 7 5800X3D and Core i9-12900K were both sold as gaming CPUs, so it only makes sense to start there. The Ryzen 7 5800X3D doesn’t support overclocking, unfortunately, though that comes with the upside of less power draw overall. The Core i9-12900K draws more than twice as much power than the Ryzen 7 5800X3D, and even more if you overclock it. Outside of specs, power is a big concern. There are some bandwidth- and latency-dependent applications that could also benefit from it, but it’s games where we’re seeing the largest benefit. That additional cache dramatically boosts the otherwise standard specifications to new heights of gaming performance. That’s more than three times as much as the Core i9-12900K. It has 64MB of 3D-stacked 元 cache on top of the die, which when combined with the normal 32MB, gives it 96MB of total 元 cache. Where the 5800X3D breaks new ground is in its cache. The AMD CPU sports a more modest 4.5GHz boost clock, a 200MHz reduction from the Ryzen 7 5800X it’s based on, while the Core i9-12900K reaches to new heights with a 5.2GHz boost clock on a single core and a 5GHz boost clock across all of them at once. The Intel Core i9-12900K has 16 total cores split between eight performance cores, and eight smaller efficiency cores. The Ryzen 7 5800X3D has a more traditional core layout of eight identical cores and 16 threads with simultaneous multi-threading. These two CPUs have very different hardware makeups, each representing exciting new directions for their respective companies. |